Celiac Disease

  • Celiac disease is a disorder characterized by intestinal malabsorption of nutrients due to sensitivity to the alcohol-soluble portion of gluten known as gliadin. Wheat, rye, barley, and to a lesser extent, oats contain this protein substance and can induce mucosal damage in the gut causing nonspecific villous atrophy of the small intestine mucosa. 
  • Most patients are asymptomatic. 
  • This disease has variable clinical manifestations that can lead to severe symptoms such as profound malabsorption, steatorrhea, and wasting. 
  • There are associations between celiac disease and Type I diabetes mellitus, thyroid disease and other autoimmune diseases.